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daily doses ranging from 600 to 3,600. Each Horizant Extended-Release Tablet contains 300 mg or 600 mg of gabapentin enacarbil and the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium stearate, sodium lauryl sulfate, and talc. Take Horizant tablets with food. The small quantity of acetaldehyde formed from gabapentin enacarbil in vivo is rapidly cleared by normal metabolic activity. The racial distribution for these studies was as follows: Caucasian, 95; black, 2; and other,. Gabapentin is effectively removed from plasma by hemodialysis. Dosage of Horizant for Patients With Restless Legs Syndrome in Accordance With Creatinine Clearance. In patients with PHN receiving Horizant twice daily, the dose should be reduced to once daily for 1 week prior to discontinuation to minimize the potential of withdrawal seizure, see Table 2 see Dosage and Administration (2.3). Call your doctor at once if you have: seizures; roco store coupon severe weakness or tiredness; problems with balance or muscle movement; upper stomach pain; chest pain, new or worsening cough with fever, trouble breathing; severe tingling or numbness; rapid eye movement; or kidney problems - little. No clinically relevant pharmacokinetic interactions are expected between Horizant and other substrates of OCT2.
Treatment of Restless Legs Syndrome. Horizant (gabapentin enacarbil) Extended-Release Tablets are indicated for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults.
The design limitations of these two studies do not permit inference regarding dose response relationship or the duration of the effect Horizant has on driving in patients with RLS. Warnings and Precautions (5.3). Renal Impairment: Gabapentin clearance after dosing with Horizant is approximately proportional to CrCl. Most of these individuals had a history of poly-substance abuse or used gabapentin to relieve symptoms of withdrawal from other substances. Have or have had seizures. Following oral dosing of Horizant, plasma clearance of gabapentin is approximately proportional to creatinine clearance. Common Horizant side effects may include: headache, dizziness, drowsiness, tiredness; swelling in your hands or feet; problems with your eyes; coordination problems; or This is not a complete list of side effects and others may occur.